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Sepantronium bromide

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Catalog No. T2111Cas No. 781661-94-7
Alias YM155

Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.

Sepantronium bromide

Sepantronium bromide

🥰Excellent
Purity: 99.82%
Catalog No. T2111Alias YM155Cas No. 781661-94-7
Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.
Pack SizePriceAvailabilityQuantity
2 mg$33In Stock
5 mg$50In Stock
10 mg$72In Stock
25 mg$151In Stock
50 mg$270In Stock
100 mg$441In Stock
500 mg$980In Stock
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Purity:99.82%
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Product Introduction

Bioactivity
Description
Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.
Targets&IC50
Survivin:0.54 nM
In vitro
Subcutaneous injection of 3 and 10 mg/kg YM155 into prostate transplantation tumors showed that YM155 completely inhibited the tumor growth of PC-3 with no decrease in weight and no decrease in blood cell count. Moreover, 5 mg/kg YM155 showed 80% tumor inhibition in PC-3 ectopic graft tumors.The combination of YM155 and γ-radiation showed high antitumor activity against H460 or Calu6 xenografts in nude mice.
In vivo
Subcutaneous injection of 3 and 10 mg/kg YM155 into prostate transplantation tumors showed that YM155 completely inhibited the tumor growth of PC-3 with no decrease in weight and no decrease in blood cell count. Moreover, 5 mg/kg YM155 showed 80% tumor inhibition in PC-3 ectopic graft tumors.The combination of YM155 and γ-radiation showed high antitumor activity against H460 or Calu6 xenografts in nude mice.
Kinase Assay
Promoter-luciferase reporter assay: A 2,767-bp sequence of human survivin gene promoter is isolated from human genomic DNA by PCR using Pyrobest polymerase and the following primers: 5
Cell Research
Cells are seeded in 96-well plates at a density of 5-40 × 103. YM155 is dissolved in DMSO and added to cells for 48 hours. Then the cell count is determined by sulforhodamine B assay. (Only for Reference)
AliasYM155
Chemical Properties
Molecular Weight443.26
FormulaC20H19BrN4O3
Cas No.781661-94-7
Smiles[Br-].COCCn1c(C)[n+](Cc2cnccn2)c2c1C(=O)c1ccccc1C2=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 82 mg/mL (185 mM)
Ethanol: 6 mg/mL (13.53 mM)
DMSO: 4.43 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO/Ethanol/H2O
1mg5mg10mg50mg
1 mM2.2560 mL11.2801 mL22.5601 mL112.8006 mL
5 mM0.4512 mL2.2560 mL4.5120 mL22.5601 mL
10 mM0.2256 mL1.1280 mL2.2560 mL11.2801 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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